Use the FollowHyperlink event
Private Sub Worksheet_FollowHyperlink(ByVal Target As Hyperlink)
'your code
End Sub
'This is worksheet event code, which means that it needs to be
'placed in the appropriate worksheet code module, not a standard
'code module. To do this, right-click on the sheet tab, select
'the View Code option from the menu, and paste the code in.

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HTH
Bob
(change the xxxx to gmail if mailing direct)
> Is there anyway I can have Excel run code on a single click in a cell?
> What I'm trying to do is I have a spreadsheet that has hyperlinks in
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>
> Thanks for any help