I have a small business and have created a data base of email addresses so I
can send out promotional material.  These emails are not attachments, they
are sent from a user template within Outlook.  When I do this I get a large
number of returns with the following error messages:

Permanent Failure:
553_sorry,_relaying_denied-from-your-location_[204.127.217.104] (#5.7.1)

550 [PERMIFAIL] destination not valid within DNS

Recipient-address-rejected:_User_unkown-in_relay_recipient_table

Permanent Failure: 550_Requestred_action_not_taken:_mailbox_unavailable

Permanent failure: 550_5_.1.1
Recipient_adddress_rejected:_User_unknown_in_relay_recipient _table

552 REQUESTED MAIL ACTION ABORTED: HEADERS EXCEED 32K BYTES OR RECORD TOO LONG

Can anyone help me to eliminate some of these problems.  I have been told
that dividing my data base into several smaller data bases would help.  And
I've been told that it would not.  If it would help, how would I go about
moving the entries in the distribution list to other distrubution lists
without having to do it manually?  I've tried copying and pasting, dragging
and dropping etc. and these are not available within the distribution list.  
HELP PLEASE!