Start here
Using Publisher for web sites
http://msmvps.com/blogs/dbartosik/articles/80566.aspx

There is a lot of information about Publisher web use on the above URL. Most of
your questions will be addressed, if not post back.

There is no obvious alignment issues on your home page. If you could be more
specific about what doesn't line up, perhaps we could make suggestions.

In the meantime, you should know that your images take way too long to load.
You should resample, resize and optimize them for the web using a third part
image editing application before you embed them into your site, and/or at
least compress them. Read "Compress graphics file sizes to create smaller
Publisher Web pages":
http://office.microsoft.com/en-us/assistance/HA011266301033.aspx

DavidF

Hi
One problem I have found is that if you put two  elongated text boxes side
by side down the page i.e. to create two colums of text, problems occur in
the second box if you CENTRE a portion of text in the first. Gaps appear in
the second column below where you centred text in the first box.