Are they crop marks? How many cards are you printing per page?

If they are crop marks, click advanced print settings in the printer dialogue,
page settings tab, clear crop marks.

Verify the settings below "File, Print"

Here's I do it with Publisher 2000.

File
Page Setup
   Special Size
   Business Card from the drop down menu
OK

Create card.

Assuming you are using standard business card stock of 2 wide and 5 high;

File
Print
   Page options button
       Print multiple copies per sheet
       Custom options button
           Margins = .5"
           Gap = 0"
           Side Margins = .75"
           Vertical gap = 0"

OK
OK
OK

And it's printing a sheet of ten cards.
Save the file and all the settings will be saved for the next batch of the
same cards.