Post the version of Publisher you plan to use.
Look for help here in the news group.

Reference: Prepare, publish, and maintain your Publisher Web site:
http://office.microsoft.com/en-us/publisher/HA100947601033.aspx
It is written for Pub 2007, but if you are using IE7 instead of IE6, then
the directions for using Vista also would apply to Pub 2003. FTP and HTTP
uploading has changed with the introduction of IE7 and Vista.

Reference: How to publish a Publisher web in HTTP:
http://msmvps.com/blogs/dbartosik/pages/80557.aspx

Reference: How to trouble-shoot Publisher web upload issues :
http://msmvps.com/blogs/dbartosik/pages/80560.aspx

If you choose to use FTP uploading then consider downloading and installing
the free FTP client FileZilla:
http://filezilla-project.org/
It is likely to be easier for you in the long run. Take the time to also
download the excellent documentation and read it.

If you have more questions about Publisher webs, then post in the web group
and we will try to help you there:
news://msnews.microsoft.com/microsoft.public.publisher.webdesign

DavidF